RHIVDB: A Freely Accessible Database of HIV Amino Acid Sequences and Clinical Data of Infected Patients

Olga Tarasova; Anastasia Rudik; Dmitry Kireev; Vladimir Poroikov

doi:10.3389/fgene.2021.679029

RHIVDB: A Freely Accessible Database of HIV Amino Acid Sequences and Clinical Data of Infected Patients

Front Genet. 2021 Jun 10:12:679029. doi: 10.3389/fgene.2021.679029. eCollection 2021.

Authors

Olga Tarasova¹, Anastasia Rudik¹, Dmitry Kireev², Vladimir Poroikov¹

Affiliations

¹ Department of Bioinformatics, Institute of Biomedical Chemistry, Moscow, Russia.
² Central Research Institute of Epidemiology, Moscow, Russia.

Abstract

Human immunodeficiency virus (HIV) infection remains one of the most severe problems for humanity, particularly due to the development of HIV resistance. To evaluate an association between viral sequence data and drug combinations and to estimate an effect of a particular drug combination on the treatment results, collection of the most representative drug combinations used to cure HIV and the biological data on amino acid sequences of HIV proteins is essential. We have created a new, freely available web database containing 1,651 amino acid sequences of HIV structural proteins [reverse transcriptase (RT), protease (PR), integrase (IN), and envelope protein (ENV)], treatment history information, and CD4+ cell count and viral load data available by the user's query. Additionally, the biological data on new HIV sequences and treatment data can be stored in the database by any user followed by an expert's verification. The database is available on the web at http://www.way2drug.com/rhivdb.

Keywords: HIV; HIV drug resistance; antiretroviral therapy; database; drug exposure; human immunodeficiency virus; sequence data analysis; therapy success.