Joint and entheseal inflammation in the knee region in spondyloarthritis - reliability and responsiveness of two OMERACT whole-body MRI scores

Marie Wetterslev; Walter P Maksymowych; Robert Gw Lambert; Iris Eshed; Susanne J Pedersen; Maria S Stoenoiu; Simon Krabbe; Paul Bird; Violaine Foltz; Ashish J Mathew; Frédérique Gandjbakhch; Joel Paschke; Philippe Carron; Gabriele De Marco; Helena Marzo-Ortega; Anna Ef Poulsen; Jacob L Jaremko; Philip G Conaghan; Mikkel Østergaard

doi:10.1016/j.semarthrit.2021.05.013

Joint and entheseal inflammation in the knee region in spondyloarthritis - reliability and responsiveness of two OMERACT whole-body MRI scores

Semin Arthritis Rheum. 2021 Aug;51(4):933-939. doi: 10.1016/j.semarthrit.2021.05.013. Epub 2021 Jun 17.

Authors

Marie Wetterslev¹, Walter P Maksymowych², Robert Gw Lambert³, Iris Eshed⁴, Susanne J Pedersen⁵, Maria S Stoenoiu⁶, Simon Krabbe⁵, Paul Bird⁷, Violaine Foltz⁸, Ashish J Mathew⁹, Frédérique Gandjbakhch⁸, Joel Paschke¹⁰, Philippe Carron¹¹, Gabriele De Marco¹², Helena Marzo-Ortega¹², Anna Ef Poulsen⁵, Jacob L Jaremko¹³, Philip G Conaghan¹², Mikkel Østergaard⁹

Affiliations

¹ Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. Electronic address: marie.wetterslev@regionh.dk.
² Department of Medicine, University of Alberta, Edmonton, Alberta, Canada; CARE Arthritis, Edmonton, Alberta, Canada.
³ Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada; Medical Imaging Consultants, Edmonton, Alberta, Canada.
⁴ Department of Diagnostic Imaging, Sheba Medical Center, Affiliated to the Sackler School of Medicine, Tel-Aviv University, Israel.
⁵ Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen, Denmark.
⁶ Department of Rheumatology, Cliniques Universitaires Saint-Luc, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Bruxelles, Belgium.
⁷ Division of Medicine, University of New South Wales, Sydney, Australia.
⁸ Department of Rheumatology, Sorbonne University, APHP, Pitié-Salpêtrière Hospital, Paris, France.
⁹ Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
¹⁰ CARE Arthritis, Edmonton, Alberta, Canada.
¹¹ Department of Rheumatology, Ghent University Hospital, Ghent, Belgium; VIB Inflammation Research Centre, Ghent University, Ghent, Belgium.
¹² Leeds Institute of Rheumatic and Musculoskeletal medicine, University of Leeds, Leeds, UK; Leeds Teaching Hospitals NHS Trust, NIHR Leeds Biomedical Research Centre, Leeds, UK.
¹³ Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada.

PMID: 34176643
DOI: 10.1016/j.semarthrit.2021.05.013

Abstract

Objective: To perform region-based development of whole-body MRI through validation of knee region scoring systems in spondyloarthritis (SpA).

Methods: Assessment of knee inflammatory pathologies using 2 systems, OMERACT MRI Whole-body score for Inflammation in Peripheral joints and Entheses (MRI-WIPE) and Knee Inflammation MRI Scoring System (KIMRISS), in 4 iterative multi-reader exercises.

Results: In the final exercise, reliability was mostly good for readers with highest agreement in previous exercise. Median pairwise single-measure ICCs for osteitis and synovitis/effusion status/change were 0.71/0.48 (WIPE-osteitis), 0.48/0.77 (WIPE-synovitis/effusion), 0.59/0.91 (KIMRISS-osteitis) and 0.92/0.97 (KIMRISS-synovitis/effusion). SRMs were 0.74 (WIPE-synovitis/effusion) and 0.78 (KIMRISS-synovitis/effusion).

Conclusion: MRI-WIPE and KIMRISS may both be useful in SpA whole-body evaluation studies.

Keywords: KIMRISS; Knee; MRI-WIPE; OMERACT; Spondyloarthritis; Whole-body MRI.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Inflammation / diagnostic imaging
Knee Joint / diagnostic imaging
Magnetic Resonance Imaging
Reproducibility of Results
Severity of Illness Index
Spondylarthritis* / complications
Spondylarthritis* / diagnostic imaging
Synovitis* / diagnostic imaging

Grants and funding

DH_/Department of Health/United Kingdom