Kidney-Specific Klotho Gene Deletion Causes Aortic Aneurysm via Hyperphosphatemia

Hypertension. 2021 Aug;78(2):308-319. doi: 10.1161/HYPERTENSIONAHA.121.17299. Epub 2021 Jun 28.

Abstract

[Figure: see text].

Keywords: alleles; aorta; cell death; osteogenesis; phosphates.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Aortic Aneurysm / genetics
  • Aortic Aneurysm / metabolism*
  • Cell Death / genetics
  • Cell Proliferation / genetics
  • Hyperphosphatemia / genetics
  • Hyperphosphatemia / metabolism*
  • Kidney / metabolism*
  • Klotho Proteins / genetics
  • Klotho Proteins / metabolism*
  • Mice
  • Mice, Knockout
  • Osteogenesis / genetics

Substances

  • Klotho Proteins