Targeting MicroRNA-192-5p, a Downstream Effector of NOXs (NADPH Oxidases), Reverses Endothelial DHFR (Dihydrofolate Reductase) Deficiency to Attenuate Abdominal Aortic Aneurysm Formation

Hypertension. 2021 Aug;78(2):282-293. doi: 10.1161/HYPERTENSIONAHA.120.15070. Epub 2021 Jun 28.

Abstract

[Figure: see text].

Keywords: NADPH oxidase; angiotensin II; aortic aneurysm, abdominal; dihydrofolate reductase; endothelial nitric oxide synthase; microRNA; oxidative stress.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aorta / drug effects
  • Aorta / metabolism*
  • Aortic Aneurysm, Abdominal / genetics
  • Aortic Aneurysm, Abdominal / metabolism*
  • Down-Regulation / drug effects
  • Endothelial Cells / drug effects
  • Endothelial Cells / metabolism
  • Endothelium, Vascular / drug effects
  • Endothelium, Vascular / metabolism*
  • Female
  • Humans
  • Hydrogen Peroxide / pharmacology
  • Male
  • MicroRNAs / genetics
  • MicroRNAs / metabolism*
  • Middle Aged
  • NADPH Oxidases / metabolism*
  • Nitric Oxide / metabolism
  • Nitric Oxide Synthase Type III / metabolism
  • Tetrahydrofolate Dehydrogenase / metabolism*

Substances

  • MIRN192 microRNA, human
  • MicroRNAs
  • Nitric Oxide
  • Hydrogen Peroxide
  • Nitric Oxide Synthase Type III
  • Tetrahydrofolate Dehydrogenase
  • NADPH Oxidases