Genetic animal models of scoliosis: A systematical review

Xin Lv; Jinghong Xu; Jiajiong Jiang; Pengfei Wu; Renchun Tan; Bing Wang

doi:10.1016/j.bone.2021.116075

Genetic animal models of scoliosis: A systematical review

Bone. 2021 Nov:152:116075. doi: 10.1016/j.bone.2021.116075. Epub 2021 Jun 24.

Authors

Xin Lv¹, Jinghong Xu¹, Jiajiong Jiang¹, Pengfei Wu¹, Renchun Tan¹, Bing Wang²

Affiliations

¹ Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China.
² Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China. Electronic address: wbxyeyy@csu.edu.cn.

PMID: 34174503
DOI: 10.1016/j.bone.2021.116075

Abstract

Scoliosis is a complex disease with undetermined pathogenesis and has a strong relationship with genetics. Models of scoliosis in animals have been established for better comprehending its pathogenesis and treatment. In this review, we searched all the genetic animal models with body curvature in databases, and reviewed the related genes and scoliosis types. Meanwhile, we also summarized the pathogenesis of scoliosis reported so far. Summarizing the positive phenotypic animal models contributes to a better understanding on the pathogenesis of scoliosis and facilitates the selection of experimental models when a possible pathogenic factor is concerned.

Keywords: Animal model; Developmental abnormality; Gene; Pathogenesis; Scoliosis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Disease Models, Animal
Scoliosis* / genetics