Channeling plant immunity

Bruno Pok Man Ngou; Pingtao Ding; Jonathan D G Jones

doi:10.1016/j.cell.2021.05.035

Channeling plant immunity

Cell. 2021 Jun 24;184(13):3358-3360. doi: 10.1016/j.cell.2021.05.035.

Authors

Bruno Pok Man Ngou¹, Pingtao Ding², Jonathan D G Jones³

Affiliations

¹ The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich NR4 7UH, UK.
² The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich NR4 7UH, UK; Institute of Biology Leiden, Leiden University, Sylviusweg 72, Leiden 2333 BE, the Netherlands. Electronic address: p.ding@biology.leidenuniv.nl.
³ The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich NR4 7UH, UK. Electronic address: jonathan.jones@tsl.ac.uk.

PMID: 34171318
DOI: 10.1016/j.cell.2021.05.035

Abstract

Plant intracellular NLR proteins detect pathogen effectors and then form multimeric protein complexes ("resistosomes") that activate immune responses and cell death through unknown mechanisms. In this issue of Cell, Bi et al. show that the ZAR1 resistosome exhibits cation channel activity, enabling calcium influx that activates defense mechanisms and culminates in cell death.

Publication types

Comment

MeSH terms

Cell Death
NLR Proteins*
Plant Immunity*
Plants
Signal Transduction

Substances

NLR Proteins