Two new sphingolipids from the stem bark of Synsepalum msolo (Sapotaceae)

Ache Roland Ndifor; Njinga Ngaitad Stanislaus; Chi Godloves Fru; Ferdinand Talontsi; Turibio Kuiate Tabopda; Elisabeth Zeuko'o Menkem; Ngadjui Bonaventure Tchaleu; Yeboah Samuel Owusu

doi:10.1016/j.bbrep.2021.101014

Two new sphingolipids from the stem bark of Synsepalum msolo (Sapotaceae)

Biochem Biophys Rep. 2021 Jun 11:27:101014. doi: 10.1016/j.bbrep.2021.101014. eCollection 2021 Sep.

Authors

Ache Roland Ndifor¹, Njinga Ngaitad Stanislaus², Chi Godloves Fru³, Ferdinand Talontsi⁴, Turibio Kuiate Tabopda³, Elisabeth Zeuko'o Menkem⁵, Ngadjui Bonaventure Tchaleu³, Yeboah Samuel Owusu⁶

Affiliations

¹ Higher Technical Teacher Training College, University of Bamenda, Cameroon.
² Department of Pharmaceutical and Medicinal Chemistry, University of Ilorin, Ilorin, Nigeria.
³ Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Cameroon.
⁴ Institute of Environmental Research (INFU), Faculty of Chemistry, TU Dortmund, Otto-Hahn-Str, 644221, Dortmund, Germany.
⁵ Department of Biochemistry, Faculty of Science, University of Yaounde I, Cameroon.
⁶ Department of Chemistry, University of Botswana, Gaborone, Botswana.

Abstract

Synsepalum msolo commonly known as Bang Bali in Bali-Nguemba, Cameroon is used in traditional medicine against various diseases. The leaves and stem bark extracts were subjected to silica gel and Sephadex LH₂₀ column chromatography to yield pure compounds. The structures of the compounds were determined by detail analysis of NMR and Mass spectroscopic data and by comparison with data reported in the literature. Amongst the isolates, were two new sphingolipids: synsepaloside B (1), synsepaloside C (2), and five known compounds: (+)-catechin (3), (-)-epicatechin (4), myricitrin (5), triacontanol (6), and aurantiamide acetate (7). Compounds 1-5 were screened for their antibacterial and anti-yeast activities on several microorganisms. All the tested compounds exhibited weak antibacterial (MIC $\geq$ 200 μg/mL) and anti-yeast (MIC > 200 μg/mL) activities as compared to standard: ciprofloxacin 0.468 < MIC >0.234 μg/mL and fluconazole MIC = 0.05 μg/mL, respectively.

Keywords: Antibacterial; Antifungal; Phytoconstituents; Sapotaceae; Synsepalum msolo.