Cyclotron-produced 68Ga from enriched 68Zn foils

Jonathan Siikanen; Emma Jussing; Stefan Milton; Carsten Steiger; Johan Ulin; Cathrine Jonsson; Erik Samén; Thuy A Tran

doi:10.1016/j.apradiso.2021.109825

Cyclotron-produced ⁶⁸Ga from enriched ⁶⁸Zn foils

Appl Radiat Isot. 2021 Oct:176:109825. doi: 10.1016/j.apradiso.2021.109825. Epub 2021 Jun 12.

Authors

Jonathan Siikanen¹, Emma Jussing², Stefan Milton², Carsten Steiger³, Johan Ulin⁴, Cathrine Jonsson⁵, Erik Samén², Thuy A Tran²

Affiliations

¹ Karolinska University Hospital, Department of Medical Radiation Physics and Nuclear Medicine, Eugeniavägen 3, SE- 171 76, Stockholm, Sweden; Karolinska Institutet, Department of Oncology and Pathology, Akademiska stråket 1, SE-171 64, Stockholm, Sweden. Electronic address: jonathan.siikanen@ki.se.
² Karolinska University Hospital, Department of Radiopharmacy, Stockholm, Sweden, Akademiska stråket 1, SE-171 64, Stockholm, Sweden; Karolinska Institutet, Department of Oncology and Pathology, Akademiska stråket 1, SE-171 64, Stockholm, Sweden.
³ Karolinska University Hospital, Department of Radiopharmacy, Stockholm, Sweden, Akademiska stråket 1, SE-171 64, Stockholm, Sweden; Karolinska Institutet, Department of Clinical Neuroscience, Akademiska stråket 1, SE-171 64, Stockholm, Sweden.
⁴ Karolinska Institutet, Department of Clinical Neuroscience, Akademiska stråket 1, SE-171 64, Stockholm, Sweden.
⁵ Karolinska University Hospital, Department of Medical Radiation Physics and Nuclear Medicine, Eugeniavägen 3, SE- 171 76, Stockholm, Sweden.

PMID: 34157495
DOI: 10.1016/j.apradiso.2021.109825

Abstract

The growing need and limited availability of generator produced ⁶⁸Ga (T_1/2 = 68 min) for PET has provided the impetus for alternative, high output, ⁶⁸Ga production routes such as charge particle activation of enriched ⁶⁸Zn using PET cyclotrons. The work presents a rapid production method for clinically useful ⁶⁸Ga for radiolabeling. The focus is also to expand the production capacity of cyclotron solid target-produced ⁶⁸Ga over generator produced and liquid solutions targets by using enriched ⁶⁸Zn-foils that minimizes target preparation.

Keywords: Cyclotron produced (68)Ga; DOTA-Based AMA; Enriched (68)Zn foils; Solid target.

MeSH terms

Cyclotrons*
Gallium Radioisotopes / chemistry*
Heterocyclic Compounds, 1-Ring / chemistry
Zinc Isotopes / chemistry*

Substances

Gallium Radioisotopes
Heterocyclic Compounds, 1-Ring
Zinc Isotopes
1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid