Utilizing magnetic resonance techniques to study membrane interactions of amyloid peptides

Biochem Soc Trans. 2021 Jun 30;49(3):1457-1465. doi: 10.1042/BST20201244.

Abstract

Alzheimer's disease (AD) is a common neurodegenerative condition that involves the extracellular accumulation of amyloid plaques predominantly consisting of Aβ peptide aggregates. The amyloid plaques and soluble oligomeric species of Aβ are believed to be the major cause of synaptic dysfunction in AD brain and their cytotoxic mechanisms have been proposed to involve interactions with cell membranes. In this review, we discuss our solid-state nuclear magnetic resonance (ssNMR) studies of Aβ interactions with model membranes.

Keywords: Alzheimers disease; NMR spectroscopy; amyloid beta; membranes; phospholipids.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alzheimer Disease / metabolism*
  • Amyloid / metabolism
  • Amyloid beta-Peptides / metabolism*
  • Amyloid beta-Protein Precursor / metabolism*
  • Brain / metabolism*
  • Brain / pathology
  • Cell Membrane / metabolism*
  • Humans
  • Magnetic Resonance Spectroscopy / methods*
  • Neurons / metabolism
  • Plaque, Amyloid / metabolism
  • Protein Binding
  • Synapses / metabolism

Substances

  • Amyloid
  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor