Lipidation status of single membrane-associated ATG8 proteins

Abstract

ATG8 are core autophagy proteins, the lipidated forms of which decorate double-membraned autophagosomes, as well as single-membraned organelles such as endolysosomes. Recent studies from the Florey and Münz laboratories delineate the status of single membrane-associated ATG8 proteins by indicating that their membrane anchoring can involve phosphatidylserine conjugation and their stabilization depends on ATG4 protease inhibition.

Keywords: ATG4 proteases; ATG8 proteins; aminoglycerophospholipids; lipidation; noncanonical autophagy; oxidation.