Advances and perspectives of aptasensors for the detection of tetracyclines: A class of model compounds of food analysis

Sai Wang; Xiaochen Yan; Yan Yang; Xiaoyan Qi; Yinglin Zhao; Ling Li; Rui Ma; Lele Wang; Yiyang Dong; Jianan Sun; Xiangzhao Mao

doi:10.1016/j.foodchem.2021.130361

Advances and perspectives of aptasensors for the detection of tetracyclines: A class of model compounds of food analysis

Food Chem. 2021 Dec 1:364:130361. doi: 10.1016/j.foodchem.2021.130361. Epub 2021 Jun 15.

Authors

Sai Wang¹, Xiaochen Yan¹, Yan Yang², Xiaoyan Qi¹, Yinglin Zhao¹, Ling Li¹, Rui Ma¹, Lele Wang¹, Yiyang Dong³, Jianan Sun⁴, Xiangzhao Mao⁵

Affiliations

¹ College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong Province 266003, China.
² College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
³ College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China. Electronic address: yydong@mail.buct.edu.cn.
⁴ College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong Province 266003, China. Electronic address: sunjianan@ouc.edu.cn.
⁵ College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong Province 266003, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao, Shandong Province 266237, China.

PMID: 34153597
DOI: 10.1016/j.foodchem.2021.130361

Abstract

The residual tetracyclines in food are frequently applied as the model compounds to develop aptasensors. Until now, more than 100 advanced aptasensors towards tetracyclines have been developed and published in English. This review summarizes and discusses comprehensively these advanced aptasensors, in terms of the principle designs, applied frontier transducers/materials, working performance, and advantages/disadvantages. The aptasensors are classified according to the inherent transduction techniques, i.e., optics, optics-electricity, optics-mass, and electricity-mass. Moreover, the present challenges such as the limited specificity and limited affinity of the aptamers, the future prospects and trends such as further combination with other advanced materials and technologies, and the urgent need of expanding the practical application were discussed and prospected. We hope this review can serve as a powerful tool for both tracing the development progresses of aptasensors and providing adequate references for further development of aptasensing methods for food-related analytes.

Keywords: Aptasensor; Electricity-mass; Optics; Optics-electricity; Optics-mass; Tetracyclines.

Publication types

Review

MeSH terms

Anti-Bacterial Agents
Aptamers, Nucleotide*
Biosensing Techniques*
Food Analysis
Tetracyclines

Substances

Anti-Bacterial Agents
Aptamers, Nucleotide
Tetracyclines