Efficacy of tailored messages to improve behavioral intent to accept HPV vaccination among mothers may be moderated by sociodemographics

Kristen A Feemster; Katharine J Head; Catherine A Panozzo; Sean M O'Dell; Gregory D Zimet; Melanie L Kornides

doi:10.1016/j.pmedr.2021.101413

Efficacy of tailored messages to improve behavioral intent to accept HPV vaccination among mothers may be moderated by sociodemographics

Prev Med Rep. 2021 May 29:23:101413. doi: 10.1016/j.pmedr.2021.101413. eCollection 2021 Sep.

Authors

Kristen A Feemster^{1

2

3}, Katharine J Head⁴, Catherine A Panozzo⁵, Sean M O'Dell^{6

7}, Gregory D Zimet⁸, Melanie L Kornides⁹

Affiliations

¹ Vaccine Education Center, Children's Hospital of Philadelphia, Philadelphia, PA.
² Division of Infectious Diseases, Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA.
³ Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
⁴ Indiana University School of Liberal Arts, Department of Communication Studies, Cavanaugh Hall 307C, 425 University Boulevard, Indianapolis, IN 46202, USA.
⁵ Moderna, 200 Technology Square, Cambridge, MA 02139, USA.
⁶ Department of Psychiatry and Behavioral Health, Geisinger, 100 North Academy Avenue, Danville, PA 17822, USA.
⁷ Department of Population Health Sciences, Geisinger, 100 North Academy Avenue, Danville, PA 17822, USA.
⁸ Department of Pediatrics, Indiana University School of Medicine, 410 West 10 Street Suite 1001, Indianapolis, IN 46202, USA.
⁹ Department of Family & Community Health, University of Pennsylvania School of Nursing, Division of Adolescent Medicine, Perelman School of Medicine, 418 Curie Boulevard, Office 401, Philadelphia, PA 19104, USA.

Abstract

We assessed differences in response to a tailored recommendation intervention for HPV vaccine by participants' sociodemographic characteristics in this exploratory sub-analysis of a larger web-based, randomized-controlled trial on tailored messaging among mothers with low intent to vaccinate their 11-14-year-old child against HPV. The intervention consisted of pre-recorded video messages tailored to 1-5 common concerns about HPV vaccine. In these exploratory analyses, we used generalized linear models to assess differences in post-intervention intent across intervention arms, stratified by sociodemographic characteristics among 496 trial participants. We found significantly higher post-intervention intent in the intervention participants versus the control group among mothers: 1) with younger children; 2) with white vs. black children; 3) with Non-Hispanic children; 4) who were younger; 5) with some college or vocational training; with household incomes of ≥$100,000; and 7) with 1-2 children. Our findings of effect modification by certain sociodemographic factors such as age, race/ethnicity, and household income should be considered when designing similar tailored messaging interventions.

Keywords: Adolescent; HPV, Human papillomavirus; Health Communication; Human Papillomavirus; RCT, Randomized controlled trial; Tailored Messaging; Vaccines.