Surface modification is an emerging strategy for the design of contact materials. Fabricated alumina discs were functionalized by deposition of biogenic silver nanoparticles. The surfaces were characterized for physico-chemical, antibacterial and antibiofilm properties against microbial pathogens. The surface demonstrated improved hydrophobicity and a surface silver nanoparticle content of 6.4 w%. A reduction of more than 99.9% in CFU mL-i was observed against the Gram-positive and Gram-negative bacteria tested, with >90% reduction of the fungal isolate. After 4 h, microbial adhesion was reduced by >99.9 and 90% for Escherichia coli and Staphylococcus aureus, respectively. Scanning electron micrographs further revealed a biofilm reduction. Cell viability tests indicated a bioincompatibility higher than 80% with Caco-2 and HaCaT cell lines after 48 h contact. The results suggest that deposition of biogenic silver nanoparticles on the surface of contact materials could be employed as a strategy to prevent biofilm formation.