Arthritis and enthesitis in the hip and pelvis region in spondyloarthritis - OMERACT validation of two whole-body MRI methods

Marie Wetterslev; Robert Gw Lambert; Walter P Maksymowych; Iris Eshed; Susanne J Pedersen; Paul Bird; Maria S Stoenoiu; Simon Krabbe; Ashish J Mathew; Violaine Foltz; Frédérique Gandjbakhch; Joel Paschke; Gabriele De Marco; Helena Marzo-Ortega; Philippe Carron; Anna Ef Poulsen; Jacob L Jaremko; Philip G Conaghan; Mikkel Østergaard

doi:10.1016/j.semarthrit.2021.05.006

Arthritis and enthesitis in the hip and pelvis region in spondyloarthritis - OMERACT validation of two whole-body MRI methods

Semin Arthritis Rheum. 2021 Aug;51(4):940-945. doi: 10.1016/j.semarthrit.2021.05.006. Epub 2021 May 21.

Authors

Marie Wetterslev¹, Robert Gw Lambert², Walter P Maksymowych³, Iris Eshed⁴, Susanne J Pedersen⁵, Paul Bird⁶, Maria S Stoenoiu⁷, Simon Krabbe⁵, Ashish J Mathew⁸, Violaine Foltz⁹, Frédérique Gandjbakhch⁹, Joel Paschke¹⁰, Gabriele De Marco¹¹, Helena Marzo-Ortega¹¹, Philippe Carron¹², Anna Ef Poulsen⁵, Jacob L Jaremko¹³, Philip G Conaghan¹¹, Mikkel Østergaard⁸

Affiliations

¹ Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. Electronic address: mariewetterslev@regionh.dk.
² Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada; Medical Imaging Consultants, Edmonton, Alberta, Canada.
³ Department of Medicine, University of Alberta, Edmonton, Alberta, Canada; CARE Arthritis, Edmonton, Alberta, Canada.
⁴ Department of Diagnostic Imaging, Sheba Medical Center, Affiliated to the Sackler School of Medicine, Tel-Aviv University, Israel.
⁵ Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark.
⁶ Division of Medicine, University of New South Wales, Sydney, Australia.
⁷ Department of Rheumatology, Cliniques Universitaires Saint-Luc, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium.
⁸ Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
⁹ Department of Rheumatology, Sorbonne Universités, APHP, Pitié-Salpêtrière Hospital, Paris, France.
¹⁰ CARE Arthritis, Edmonton, Alberta, Canada.
¹¹ Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom; NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom.
¹² Department of Rheumatology, Ghent University Hospital, Ghent, Belgium; VIB Inflammation Research Centre, Ghent University, Ghent, Belgium.
¹³ Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada.

PMID: 34140185
DOI: 10.1016/j.semarthrit.2021.05.006

Abstract

Objective: To validate reliability, correlation and responsiveness of two whole-body MRI scores for the hip/pelvis region in spondyloarthritis.

Methods: Assessment of hip/pelvis inflammation in 4 multi-reader exercises using the OMERACT MRI Whole-body score for Inflammation in Peripheral joints and Entheses (MRI-WIPE) and Hip Inflammation Magnetic Resonance Imaging Scoring System (HIMRISS).

Results: In exercises 3-4 (11/20 cases, respectively; 9 readers) reliability was mostly good for the 3 best calibrated readers. Median pairwise single-measure ICC for status were 0.58-0.65 (WIPE-osteitis), 0.10-0.88 (HIMRISS-osteitis) and for status/change 0.38-0.72/0.52-0.60 (WIPE-synovitis/effusion) and 0.68-0.89/0.78-0.85 (HIMRISS-synovitis/effusion). SRM was 1.23 for WIPE-osteitis, while lower for WIPE-synovitis/effusion and HIMRISS.

Conclusion: MRI-WIPE and HIMRISS may after further validation be useful in future spondyloarthritis trials.

Keywords: HIMRISS; Hip; MRI-WIPE; OMERACT; Spondyloarthritis; Whole-body MRI.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Magnetic Resonance Imaging
Pelvis
Reproducibility of Results
Severity of Illness Index
Spondylarthritis* / diagnostic imaging

Grants and funding

DH_/Department of Health/United Kingdom