Treg and IL-1 receptor type 2-expressing CD4+ T cell-deleted CD4+ T cell fraction prevents the progression of age-related hearing loss in a mouse model

J Neuroimmunol. 2021 Aug 15:357:577628. doi: 10.1016/j.jneuroim.2021.577628. Epub 2021 Jun 8.

Abstract

We investigated the association between cellular immunity and age-related hearing loss (ARHL) development using three CD4+ T cell fractions, namely, naturally occurring regulatory T cells (Treg), interleukin 1 receptor type 2-expressing T cells (I1R2), and non-Treg non-I1R2 (nTnI) cells, which comprised Treg and I1R2-deleted CD4+ T cells. Inoculation of the nTnI fraction into a ARHL murine model, not only prevented the development of ARHL and the degeneration of spiral ganglion neurons, but also suppressed serum nitric oxide, a source of oxidative stress. Further investigations on CD4+ T cell fractions could provide novel insights into the prevention of aging, including presbycusis.

Keywords: Age-related hearing loss; CD4(+) T cell; Interleukin 1 receptor type 2; Naturally occurring regulatory T cells; Nitrogen oxide; Spiral ganglion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / transplantation*
  • Disease Models, Animal
  • Disease Progression
  • Mice
  • Presbycusis / immunology*
  • Presbycusis / prevention & control*
  • Receptors, Interleukin-1 Type II / immunology
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocyte Subsets / transplantation*
  • T-Lymphocytes, Regulatory / immunology

Substances

  • Receptors, Interleukin-1 Type II