The HECT family of E3 ubiquitin ligases and PTEN

Semin Cancer Biol. 2022 Oct:85:43-51. doi: 10.1016/j.semcancer.2021.06.012. Epub 2021 Jun 12.

Abstract

Members of the HECT family of E3 ubiquitin ligases have emerged as prominent regulators of PTEN function, subcellular localization and levels. In turn this unfolding regulatory network is allowing for the identification of genes directly involved in both tumorigenesis at large and cancer susceptibility syndromes. While the complexity of this regulatory network is still being unraveled, these new findings are paving the way for novel therapeutic modalities for cancer prevention and therapy as well as for other diseases. Here we will review the signal transduction and therapeutic implications of the cross-talk between HECT family members and PTEN.

Keywords: HECT family of E3 ubiquitin ligase; I3C; NEDD4; PTEN; WWP1.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Carcinogenesis
  • Humans
  • Neoplasms* / enzymology
  • Neoplasms* / genetics
  • PTEN Phosphohydrolase* / genetics
  • PTEN Phosphohydrolase* / metabolism
  • Ubiquitin-Protein Ligases* / genetics
  • Ubiquitin-Protein Ligases* / metabolism
  • Ubiquitination

Substances

  • PTEN Phosphohydrolase
  • PTEN protein, human
  • Ubiquitin-Protein Ligases