Potential Drugs for the Treatment of COVID-19: Synthesis, Brief History and Application

Ekhlass Uddin; Raisul Islam; Ashrafuzzaman; Nur Amin Bitu; Md Saddam Hossain; Abm Nazmul Islam; Ali Asraf; Faruk Hossen; Ranjan K Mohapatra; Md Kudrat-E-Zahan

doi:10.2174/2589977513666210611155426

Potential Drugs for the Treatment of COVID-19: Synthesis, Brief History and Application

Curr Drug Res Rev. 2021;13(3):184-202. doi: 10.2174/2589977513666210611155426.

Authors

Affiliations

¹ Department of Chemistry, Rajshahi University, Rajshahi 6205, Bangladesh.
² Department of Chemistry, Begum Rokeya University, Rangpur, Bangladesh.
³ Chemistry Discipline, Khulna University, Khulna-9208, Bangladesh.
⁴ Department of Chemistry, Government College of Engineering, Keonjhar, Odisha, India.

PMID: 34126913
DOI: 10.2174/2589977513666210611155426

Abstract

Coronaviruses (CoVs) belong to the Betacoronavirus group, an unusually large RNA genome characterized by club-like spikes that project from their surface. An outbreak of a novel coronavirus 2019 (nCOVID-19) already showed a unique replication strategy and infection that has posed significant threat to international health and the economy around the globe. Scientists around the world are investigating few previously used clinical drugs for the treatment of COVID-19. This review provides synthesis and mode of action of recently investigated drugs like Chloroquine, Hydroxychloroquine, Ivermectin, Selamectin, Remdesivir, Baricitinib, Darunavir, Favipiravir, Lopinavir/ ritonavir and Mefloquine hydrochloride that constitute an option for COVID-19 treatment.

Keywords: COVID-19 treatment.; Coronavirus; antiviral therapies; drug synthesis; nCOVID-19; pandemic disease.

Publication types

Review

MeSH terms

Antiviral Agents / therapeutic use
COVID-19 Drug Treatment*
Humans
Hydroxychloroquine
SARS-CoV-2

Substances

Antiviral Agents
Hydroxychloroquine