A comprehensive review on gout: The epidemiological trends, pathophysiology, clinical presentation, diagnosis and treatment

J Pak Med Assoc. 2021 Apr;71(4):1234-1238. doi: 10.47391/JPMA.313.

Abstract

The current review was planned to assess updated knowledge about gout and to highlight the various areas which need to be focussed upon for better healthcare. Relevant articles published in English language were reviewed by utilising various databases including Google Scholar, Springer Link, Science Direct and MEDLINE. Data revealed a precipitating number of gout cases from the developed countries, while the developing countries on the other hand were found to be faced with an even higher threat. The risk factors and pathophysiology of gout are immaculate and clearly established. Hence, appropriate measures can be explored and worked on to pinpoint diagnosis, and economical treatment. In order to lessen the elevated global health burden along with revolutionising the patient's quality of life, an immediate action is required in certain aspects, like the adoption of a healthy modified lifestyle, a reduction in exposure to risk factors, robust prophylactic measures, bettering awareness, and an approach to early diagnosis followed by optimal treatment protocols.

Keywords: Gout, Inflammation, Hyperuricemia, Allopurinol, Xanthine oxidase..

Publication types

  • Review

MeSH terms

  • Gout Suppressants* / therapeutic use
  • Gout* / diagnosis
  • Gout* / epidemiology
  • Gout* / therapy
  • Humans
  • Quality of Life
  • Risk Factors

Substances

  • Gout Suppressants