Revisiting Surgical Strategies for Hepatocellular Carcinoma With Microvascular Invasion

Er-Lei Zhang; Qi Cheng; Zhi-Yong Huang; Wei Dong

doi:10.3389/fonc.2021.691354

Revisiting Surgical Strategies for Hepatocellular Carcinoma With Microvascular Invasion

Front Oncol. 2021 May 27:11:691354. doi: 10.3389/fonc.2021.691354. eCollection 2021.

Authors

Er-Lei Zhang^{1

2}, Qi Cheng^{1

2}, Zhi-Yong Huang^{1

2}, Wei Dong^{1

2}

Affiliations

¹ Hepatic Surgery Center, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.
² Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China.

Abstract

Although liver resection (LR) and liver transplantation (LT) are widely considered as potentially curative therapies for selected patients with hepatocellular carcinoma (HCC); however, there is still high risk of tumor recurrence in majority of HCC patients. Previous studies demonstrated that the presence of microvascular invasion (MVI), which was defined as the presence of tumor emboli within the vessels adjacent to HCC, was one of the key factors of early HCC recurrence and poor surgical outcomes after LR or LT. In this review, we evaluated the impact of current MVI status on surgical outcomes after curative therapies and aimed to explore the surgical strategies for HCC based on different MVI status with evidence from pathological examination. Surgical outcomes of HCC patients with MVI have been described as a varied range after curative therapies due to a broad spectrum of current definitions for MVI. Therefore, an international consensus on the validated definition of MVI in HCC is urgently needed to provide a more consistent evaluation and reliable prediction of surgical outcomes for HCC patients after curative treatments. We concluded that MVI should be further sub-classified into MI (microvessel invasion) and MPVI (microscopic portal vein invasion); for HCC patients with MPVI, local R0 resection with a narrow or wide surgical margin will get the same surgical results. However, for HCC patients with MI, local surgical resection with a wide and negative surgical margin will get better surgical outcomes. Nowadays, MVI status can only be reliably confirmed by histopathologic evaluation of surgical specimens, limiting its clinical application. Taken together, preoperative assessment of MVI is of utmost significance for selecting a reasonable surgical modality and greatly improving the surgical outcomes of HCC patients, especially in those with liver cirrhosis.

Keywords: hepatocellular carcinoma; liver resection; liver transplantation; microvascular invasion; sub-classification; surgical strategy.

Publication types

Review