Abstract
Belamcandaoids A-N (1-14), fourteen new triterpenoids were isolated from the seeds of Belamcanda chinensis. Their structures including absolute configurations were assigned by using spectroscopic, computational, and crystallographic methods. All the compounds except 1 and 2 are 3,4-seco-triterpenoids belonging to fernane type. Biological evaluation results indicated that 3 and 13 could reduce fibronectin and collagen I expression respectively in TGF-β1 induced kidney proximal tubular cells.
Keywords:
Belamcanda chinensis; Kidney proximal tubular cells; TGF-β1; Triterpenoids.
Copyright © 2021. Published by Elsevier Inc.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Line
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Density Functional Theory
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Dose-Response Relationship, Drug
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Epithelial Cells / drug effects*
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Epithelial Cells / metabolism
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Extracellular Matrix / drug effects*
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Extracellular Matrix / metabolism
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Iridaceae / chemistry*
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Kidney Tubules, Proximal / drug effects
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Kidney Tubules, Proximal / metabolism
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Molecular Structure
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Rats
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Seeds / chemistry
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Structure-Activity Relationship
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Transforming Growth Factor beta1 / antagonists & inhibitors*
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Transforming Growth Factor beta1 / metabolism
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Triterpenes / chemistry
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Triterpenes / isolation & purification
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Triterpenes / pharmacology*
Substances
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Plant Extracts
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Transforming Growth Factor beta1
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Triterpenes