Study on bisphenol F, a bisphenol A analogue, at a dairy company: Health hazard and risk assessment

Abstract

The occurrence of analogues of bisphenol A (BPA), including bisphenol F(BPF) in milk is still not well known. BPF may enter the milk chain at the farm and during milk processing at the dairy company. This study identified the main BPF contamination pathways using a monitoring model based on the identification of the hazard at three stages along the dairy chain: raw milk from the storage tank, pasteurized milk from the storage tank, and cardboard packaged milk. Quantitative analysis was performed by high-performance liquid chromatography with fluorometric detection (HPLC/FD) system. BPF was detected in all analysed stages (from <LOQ to 2.686 μg/L). The structural and toxicological similarity between BPF and BPA suggested considering both bisphenols for a more comprehensive risk evaluation. The daily intake of BPF and of the sum of BPF and BPA, and the worst-case scenario through the consumption of packaged milk were calculated. Exposure levels below the temporary daily intake, fixed for only BPA, were detected in all consumer age classes. Nevertheless, the use of BPA substitutes represents a risk to human health because of their potential synergic effects. The application of a monitoring program at each stage of milk processing at the dairy company may represent a useful strategy to ensure food safety in the milk chain.

Keywords: Bisphenol F; Bisphenol a; Exposure; Milk processing; Risk assessment.