This paper represents the efficiency of machine learning tool, i.e., artificial neural network (ANN), for the prediction of functional properties of nano titanium dioxide coated cotton composites. A comparative analysis was performed between the predicted results of ANN, multiple linear regression (MLR) and experimental results. ANN was applied to map out the complex input-output conditions to predict the optimal results. A backpropagation ANN model called a multilayer perceptron (MLP), trained with Bayesian regularization were used in this study. The amount of chemicals and reaction time were selected as input variables and the amount of titanium dioxide coated on cotton, self-cleaning efficiency, antimicrobial efficiency and ultraviolet protection factor were analysed as output results. The accuracy of the proposed algorithm was evaluated and compared with MLR results. The obtained results reveal that MLP provides efficient results that are statistically significant in the prediction of functional properties ([Formula: see text]) compared to MLR. The correlation coefficient of MLP model ([Formula: see text]) indicates that there is a strong correlation between the measured and predicted functional properties with a trivial mean absolute error and root mean square errors values. MLP model is suitable for the functional properties and can be used for the investigation of other properties of nano coated fabrics.