Cardiorespiratory Coordination in Hypercapnic Test Before and After High-Altitude Expedition

Valentina V Gultyaeva; Dmitriy Y Uryumtsev; Margarita I Zinchenko; Vladimir N Melnikov; Natalia V Balioz; Sergey G Krivoschekov

doi:10.3389/fphys.2021.673570

Cardiorespiratory Coordination in Hypercapnic Test Before and After High-Altitude Expedition

Front Physiol. 2021 May 24:12:673570. doi: 10.3389/fphys.2021.673570. eCollection 2021.

Authors

Valentina V Gultyaeva¹, Dmitriy Y Uryumtsev¹, Margarita I Zinchenko¹, Vladimir N Melnikov¹, Natalia V Balioz¹, Sergey G Krivoschekov¹

Affiliation

¹ Laboratory of Functional Reserves of Human Organism, Scientific Research Institute of Neurosciences and Medicine, Novosibirsk, Russia.

Abstract

Coordination of cardiovascular and respiratory systems enables a wide range of human adaptation and depends upon the functional state of an individual organism. Hypoxia is known to elicit changes in oxygen and carbon dioxide sensitivity, while training alters cardiorespiratory coordination (CRC). The delayed effect of high altitude (HA) acclimatization on CRC in mountaineers remains unknown. The objective of this study was to compare CRC in acute hypercapnia in mountaineers before and after a HA expedition. Nine trained male mountaineers were investigated at sea level before (Pre-HA) and after a 20-day sojourn at altitudes of 4,000-7,000 m (Post-HA) in three states (Baseline, Hypercapnic Rebreathing, and Recovery). A principal component (PC) analysis was performed to evaluate the CRC. The number of mountaineers with one PC increased Post-HA (nine out of nine), compared to Pre-HA (five out of nine) [Chi-square (df = 1) = 5.14, P = 0.023]; the percentage of total variance explained by PC1 increased [Pre-HA median 65.6 (Q1 64.9/Q3 74.9), Post-HA 75.6 (73.3/77.9), P = 0.028]. Post-HA, the loadings of the expired fraction of O2, CO2, and ventilation onto PC1 did not change, and the loading of heart rate increased [Pre-HA 0.64 (0.45/0.68) and Post-HA 0.76 (0.65/0.82), P = 0.038]. During the Recovery, the percentage of total variance explained by PC1 was higher than during the Baseline. Post-HA, there was a high correlation between the Exercise addiction scores and the eigenvalues of PC1 (r = 0.9, P = 0.001). Thus, acute hypercapnic exposure reveals the Post-HA increase in cardiorespiratory coordination, which is highly related to the level of exercise addiction.

Keywords: cardiorespiratory coordination; exercise addiction; high altitude; hypercapnia; mountaineers; principal component analysis; rebreathing.