Generic nature of the condensed states of proteins

Nat Cell Biol. 2021 Jun;23(6):587-594. doi: 10.1038/s41556-021-00697-8. Epub 2021 Jun 9.

Abstract

Proteins undergoing liquid-liquid phase separation are being discovered at an increasing rate. Since at the high concentrations present in the cell most proteins would be expected to form a liquid condensed state, this state should be considered to be a fundamental state of proteins along with the native state and the amyloid state. Here we discuss the generic nature of the liquid-like and solid-like condensed states, and describe a wide variety of biological functions conferred by these condensed states.

Publication types

  • Review

MeSH terms

  • Animals
  • Evolution, Molecular
  • Gene Expression Regulation
  • Humans
  • Intrinsically Disordered Proteins / chemistry
  • Intrinsically Disordered Proteins / metabolism
  • Models, Molecular
  • Protein Conformation
  • Protein Folding
  • Protein Processing, Post-Translational
  • Proteins / chemistry*
  • Proteins / metabolism
  • Signal Transduction
  • Structure-Activity Relationship

Substances

  • Intrinsically Disordered Proteins
  • Proteins