A no-Wnt situation for alveolar macrophage self-renewal

Tomeka Suber; Matthew J Camiolo; Anuradha Ray

doi:10.1016/j.immuni.2021.05.013

A no-Wnt situation for alveolar macrophage self-renewal

Immunity. 2021 Jun 8;54(6):1099-1101. doi: 10.1016/j.immuni.2021.05.013.

Authors

Tomeka Suber¹, Matthew J Camiolo², Anuradha Ray³

Affiliations

¹ Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA USA.
² Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA USA; Center for Systems Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA USA.
³ Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA USA. Electronic address: raya@pitt.edu.

Abstract

Alveolar macrophages (AMs) are central to defense against respiratory pathogens. Impediments in restoring AMs after infection increase the risk for superinfection, which is associated with significant morbidity and mortality worldwide. In this issue of Immunity, Zhu et al. report a Wnt-β-catenin-HIF-1α axis in AMs that promotes an inflammatory phenotype while restricting proliferation and self-renewal.

Publication types

Comment

MeSH terms

Macrophages, Alveolar*
Phenotype