Emerging data have demonstrated that bone marrow mesenchymal stem cells (MSCs) play important roles in the progression of myelodysplastic syndrome (MDS). Experiments in vitro have showed that MSCs derived from MDS patients (MDS-MSC) exhibit the biological characteristics of cell senescence. Although the underlying mechanisms that regulate cell senescence need to be further elucidated, existing researches indicate that the mechanisms of MDS-MSC senescence have significant heterogeneity. Depth understanding of the underlying mechanisms involved in cell senescence of MDS-MSC are crucial to explore the potential therapeutic target of MDS. Therefore, this review summarizes research advances related with MSC senescence, such as MDS-MSC intrinsic changes in telomere shortening, DNA methylation status, oxidative stress and signal pathways regulating cell senescence in recent years.
题目: 骨髓增生异常综合征患者来源的骨髓间充质干细胞衰老机制的研究进展.
摘要: 越来越多的研究表明，骨髓间充质干细胞（MSC）在骨髓增生异常综合征（MDS）的进展过程中发挥了重要作用。体外实验显示，MDS患者的MSC（MDS-MSC）展现出细胞衰老的生物学特点。尽管调控细胞衰老的潜在机制有待深入研究，但现有的研究表明MDS-MSC细胞衰老的机制具有显著的异质性。加深对MDS-MSC衰老潜在机制的认识有助于促进MDS新治疗靶点的探索。因此，本文对MDS-MSC细胞衰老相关端粒长度内在改变、DNA甲基化状态、氧化应激、调控细胞衰老的基因和信号通路方面的研究进展进行总结.