C21, C22 pregnane glycosides and cytotoxic C27 spriostanol steroids from Asparagus cochinchinesis

Steroids. 2021 Aug:172:108874. doi: 10.1016/j.steroids.2021.108874. Epub 2021 Jun 5.

Abstract

A preliminary chemical investigation on 70% MeOH extract of the roots of Asparagus cochinchinensis resulted in the isolation of nine steroids. These isolates comprised of four new C21 (1-4) and one new pregnane (5) glycosides, and four known C27 (6-9) spirostanol steroids. Their structures were identified via analysis of the spectroscopic data and the results of hydrolytic cleavage. The cytotoxic activities of the compounds were tested toward the human tumor cell line Hela (cervical cancer), and compounds 7 and 8 displayed moderate activity with IC50 values of 35.5 and 39.6 μM, respectively.

Keywords: Asparagus cochinchinensis; C(21) pregnane glycosides; C(22) pregnane glycosides; Cytotoxic steroids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Apocynaceae / chemistry*
  • Cell Proliferation
  • Female
  • Glycosides / pharmacology*
  • Humans
  • Molecular Structure
  • Plant Extracts / pharmacology*
  • Plant Roots / chemistry
  • Pregnanes / pharmacology*
  • Steroids / pharmacology*
  • Uterine Cervical Neoplasms / drug therapy*
  • Uterine Cervical Neoplasms / pathology

Substances

  • Antineoplastic Agents, Phytogenic
  • Glycosides
  • Plant Extracts
  • Pregnanes
  • Steroids
  • pregnane glycoside