Cerebellitis in a human T-lymphotropic virus type 1 carrier: a case report

BMJ Case Rep. 2021 Jun 7;14(6):e241366. doi: 10.1136/bcr-2020-241366.

Abstract

Human T-lymphotropic virus type I (HTLV-I) is a retrovirus associated with adult T-cell lymphoma (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). In addition to HAM/TSP and ATL, HTLV-I-associated encephalopathy and cerebellar involvement have been reported. We report a case of an 87-year-old Japanese woman presenting with progressive dysarthria and gait disturbance. Neurological examination showed word-finding difficulty, scanning speech, saccadic eye movements, ocular dysmetria, gaze-evoked nystagmus and bilateral dysmetria. There was no motor weakness or spasticity. HTLV-I antibody was detected in both her serum and cerebrospinal fluid. Cerebrospinal fluid neopterin (57 pg/mL) and IgG index (3.27) were significantly elevated. MRI showed cerebellar swelling. She was finally diagnosed with HTLV-I associated cerebellitis. Two courses of high-dose intravenous methylpredonine therapy attenuated cerebellar ataxia and cerebellar swelling. It suggests that cerebellitis can result from HTLV-I infection, regardless of the existence of ATL or HAM/TSP.

Keywords: brain stem / cerebellum; infection (neurology).

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged, 80 and over
  • Cerebellar Ataxia* / diagnosis
  • Cerebellar Ataxia* / etiology
  • Female
  • HTLV-I Infections* / complications
  • HTLV-I Infections* / diagnosis
  • HTLV-I Infections* / drug therapy
  • Human T-lymphotropic virus 1*
  • Humans
  • Leukemia-Lymphoma, Adult T-Cell*
  • Nystagmus, Pathologic*
  • Paraparesis, Tropical Spastic* / complications
  • Paraparesis, Tropical Spastic* / diagnosis
  • Paraparesis, Tropical Spastic* / drug therapy