3-Dimensional Bioprinting of Cardiovascular Tissues: Emerging Technology

Kevin Sung; Nisha R Patel; Nureddin Ashammakhi; Kim-Lien Nguyen

doi:10.1016/j.jacbts.2020.12.006

3-Dimensional Bioprinting of Cardiovascular Tissues: Emerging Technology

JACC Basic Transl Sci. 2021 May 24;6(5):467-482. doi: 10.1016/j.jacbts.2020.12.006. eCollection 2021 May.

Authors

Kevin Sung^{1

2}, Nisha R Patel^{1

2

3}, Nureddin Ashammakhi^{4

5}, Kim-Lien Nguyen^{1

2

5

6}

Affiliations

¹ Division of Cardiology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
² Division of Cardiology, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, USA.
³ Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois, USA.
⁴ Department of Biomedical Engineering, Henry Samueli School of Engineering, University of California-Los Angeles, Los Angeles, California, USA.
⁵ Department of Radiology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
⁶ Physics and Biology in Medicine Graduate Program, University of California-Los Angeles, Los Angeles, California, USA.

Abstract

Three-dimensional (3D) bioprinting may overcome challenges in tissue engineering. Unlike conventional tissue engineering approaches, 3D bioprinting has a proven ability to support vascularization of larger scale constructs and has been used for several cardiovascular applications. An overview of 3D bioprinting techniques, in vivo translation, and challenges are described.

Keywords: 3-dimensional; 3D, 3-dimensional; ECM, extracellular matrix; HUVEC, human umbilical vein endothelial cell(s); MSC, mesenchymal stem cell(s); UV, ultraviolet; bioink; bioprinting; cardiovascular disease; hCPC, human cardiac-derived progenitor cell(s); hiPSC, human induced-pluripotent stem cell(s); regenerative medicine; tissue engineering.

Publication types

Review