Management of Persistent Corneal Epithelial Defects with Human Amniotic Membrane-derived Dry Matrix

Sundas Maqsood; Kareem Elsawah; Navpreet Dhillon; Shady Soliman; Masara Laginaf; Vaishali Lodhia; Damian Lake; Samer Hamada; Mohamed Elalfy

doi:10.2147/OPTH.S299141

Management of Persistent Corneal Epithelial Defects with Human Amniotic Membrane-derived Dry Matrix

Clin Ophthalmol. 2021 May 28:15:2231-2238. doi: 10.2147/OPTH.S299141. eCollection 2021.

Authors

Sundas Maqsood^{1

2}, Kareem Elsawah³, Navpreet Dhillon¹, Shady Soliman³, Masara Laginaf², Vaishali Lodhia², Damian Lake¹, Samer Hamada¹, Mohamed Elalfy^{1

2

3}

Affiliations

¹ Corneo-Plastic Unit, Queen Victoria Hospital NHS, East Grinstead, UK.
² Eye Department, Maidstone and Turnbridge Wells Hospitals, Maidstone, UK.
³ Cornea Department, Research Institute of Ophthalmology, Giza, Egypt.

Abstract

Objective: To report the outcomes of using human amniotic membrane-derived dry matrix (AMDDM) in the management of persistent corneal epithelial defects (PEDs) of various etiologies.

Methods: A cohort study of 84 patients age range 7 to 92 years with 93 PEDs were treated with AMDDM (Omnigen^® using OmniLenz^® at two centers (Queen Victoria Hospital and Maidstone Hospital) in the UK. The main outcome measures were healing response of PED and time to heal after application of AMDDM.

Results: A total of 106 applications of AMDDM were recorded for 81 patients (52 males, 29 females) with a spectrum of different etiologies. Fifty-eight percent of the eyes showed complete healing, and 28% showed partial decrease of the size of PEDs with average treatment length recorded as 22.4±12.3 days. In patients with limbal stem cell deficiency (n=44; aniridia=12, chemical injury=9, Stevens-Johnson syndrome=10), 50% of PEDs showed complete healing and 27% showed partial healing. In patients with microbial keratitis (n=21) (bacterial: 13, fungal: 4, herpetic: 3, acanthamoeba: 1) 57% of PEDs showed complete healing and 33% were partially healed. In patients with keratoplasty (n=16), 56% of PEDs showed complete healing and 31% were partially healed. Vision remained stable in 59% and improved in 27% of the study the population.

Conclusion: AMDDM can be easily applied in the clinical setting and has demonstrated its efficiency as a new tool to treat persistent epithelial defects.

Keywords: amniotic membrane derived dry matrix; persistent epithelial defects; suture less amniotic membrane.

Grants and funding

There is no funding to report.