Novel Orally Formulated Mixed Micelles Optimize Vitamin K Absorption Under Bile-Deficient Conditions

Gastroenterology. 2021 Sep;161(3):1056-1059.e5. doi: 10.1053/j.gastro.2021.05.056. Epub 2021 Jun 4.

Lipophilic Drug Delivery Despite Cholestasis Study Group:
M Rodriguez³, F Sun⁵, C Oussoren⁵, T K Slot⁵, M van der Ham⁷, G E P J Janssens⁵, M G M de Sain-van der Velden⁷, R H J Houwen⁸, T J de Koning⁹, W E Hennink⁵

¹ Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands; Research and Development Department, Tiofarma BV, Oud-Beijerland, the Netherlands. Electronic address: t.rooimans@uu.nl.
² Section Acute Medicine, Department of Internal Medicine, Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
³ Drug Modeling & Consulting Group, Dynakin SL, Bilbao, Spain.
⁴ Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands; Research and Development Department, Tiofarma BV, Oud-Beijerland, the Netherlands.
⁵ Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.
⁶ Department of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands. Electronic address: t.rooimans@uu.nl.
⁷ Section Metabolic Diagnostics, Department of Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
⁸ Department of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands.
⁹ Pediatrics, Department of Clinical Sciences, Lund University, Lund, Sweden.

No abstract available

Keywords: Bioavailability; Cholestasis; Mixed Micelles; Vitamin K Deficiency Bleeding; Vitamin K Prophylaxis.

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