Lignans from Lepidium meyenii and Their Anti-Inflammatory Activities

Chem Biodivers. 2021 Aug;18(8):e2100231. doi: 10.1002/cbdv.202100231. Epub 2021 Jun 17.

Abstract

Meyeniines A-C (1-3), three new lignans, two known neolignans (4-5), and three known lignans (6-8) were isolated from the rhizomes of Lepidium meyenii. Their structures were identified by comprehensive spectroscopic analyses and computational methods. Compound 1 represents a unique lignan featuring an aromatic ring migration. Compounds 2 and 4-6 were analyzed by chiral HPLC column as enantiomers. Biological evaluation revealed that compound 8 could inhibit IL-6 production in lipopolysaccharide (LPS) induced RAW264.7 cells in a dose-dependent manner.

Keywords: Lepidium meyenii; anti-inflammatory activity; lignans; meyeniines A-C.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemistry*
  • Anti-Inflammatory Agents / isolation & purification
  • Anti-Inflammatory Agents / pharmacology
  • Cell Survival / drug effects
  • Interleukin-6 / metabolism
  • Lepidium / metabolism*
  • Lignans / chemistry*
  • Lignans / isolation & purification
  • Lignans / pharmacology
  • Lipopolysaccharides / pharmacology
  • Macrophages / cytology
  • Macrophages / drug effects
  • Macrophages / metabolism
  • Magnetic Resonance Spectroscopy
  • Mice
  • Molecular Conformation
  • Plant Extracts / chemistry
  • RAW 264.7 Cells

Substances

  • Anti-Inflammatory Agents
  • Interleukin-6
  • Lignans
  • Lipopolysaccharides
  • Plant Extracts