An efficient and practical synthetic procedure for libraries of diversified 1,2-dihydrochromeno[2,3-c]pyrrole-3,9-diones using a multicomponent process is presented. A convenient synthetic procedure for obtaining functionalized 3-(2-hydroxyphenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones via ring-opening strategy has also been developed. This protocol was found to be compatible with a wide range of substituents and paves the way for the practical synthesis of title compounds with a broad range of substituents under mild condition. The products can be easily isolated by crystallization without the use of chromatography.
Keywords: Chromeno[2,3-c]pyrroles; Combinatorial library; Dihydrochromeno[2,3-c]pyrrole-3,9-diones; Dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones; Multicomponent cyclization.
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