Major histocompatibility complex Class II-based therapy for stroke

Bella M Gonzales-Portillo; Jea-Young Lee; Arthur A Vandenbark; Halina Offner; Cesario V Borlongan

doi:10.4103/bc.bc_16_21

Major histocompatibility complex Class II-based therapy for stroke

Brain Circ. 2021 Mar 30;7(1):37-40. doi: 10.4103/bc.bc_16_21. eCollection 2021 Jan-Mar.

Authors

Bella M Gonzales-Portillo¹, Jea-Young Lee², Arthur A Vandenbark^{3

4

5}, Halina Offner^{4

6}, Cesario V Borlongan²

Affiliations

¹ Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
² Department of Neurosurgery and Brain Repair, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
³ Department of Veterans Affairs, Veterans Affairs Portland Health Care System, Portland, OR, USA.
⁴ Department of Neurology, Oregon Health and Science University, Portland, OR, USA.
⁵ Department of Molecular Microbiology and Immunology and Anaesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA.
⁶ Department of Anaesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA.

Abstract

This review discusses the potential of major histocompatibility complex (MHC) Class II constructs as stroke therapeutics. We focus on the delivery of MHC Class II construct, DRmQ, as a safe and effective treatment for ischemic stroke. DRmQ was observed to attenuate behavioral deficits and decrease microglia activation and proinflammatory cytokines, illustrating its ability to mitigate the secondary cell death following stroke. Similar anti-neuroinflammation treatments, such as transplantation of mesenchymal stem cells and mitochondrial transfers, are briefly discussed to provide further support that sequestration of inflammation stands as a robust therapeutic target for stroke.

Keywords: Cell death; DRmQ; cytokines; mesenchymal stem cell; mitochondrial transfer; stem cell therapy; stroke therapy.

Publication types

Review

Abstract

Publication types

Grants and funding