Advancing Raman spectroscopy from research to clinic: Translational potential and challenges

Swati Tanwar; Santosh Kumar Paidi; Ram Prasad; Rishikesh Pandey; Ishan Barman

doi:10.1016/j.saa.2021.119957

Advancing Raman spectroscopy from research to clinic: Translational potential and challenges

Spectrochim Acta A Mol Biomol Spectrosc. 2021 Nov 5:260:119957. doi: 10.1016/j.saa.2021.119957. Epub 2021 May 13.

Authors

Swati Tanwar¹, Santosh Kumar Paidi¹, Ram Prasad², Rishikesh Pandey³, Ishan Barman⁴

Affiliations

¹ Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD 21218, United States.
² Department of Botany, School of Life Sciences, Mahatma Gandhi Central University, Motihari, Bihar 845401, India.
³ CytoVeris Inc., Farmington, CT 06032, United States; Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, United States. Electronic address: rishikesh.pandey@uconn.edu.
⁴ Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD 21218, United States; The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, School of Medicine, Baltimore, MD 21205, United States; Department of Oncology, Johns Hopkins University, Baltimore, MD 21287, United States. Electronic address: ibarman@jhu.edu.

PMID: 34082350
DOI: 10.1016/j.saa.2021.119957

Abstract

Raman spectroscopy has emerged as a non-invasive and versatile diagnostic technique due to its ability to provide molecule-specific information with ultrahigh sensitivity at near-physiological conditions. Despite exhibiting substantial potential, its translation from optical bench to clinical settings has been impacted by associated limitations. This perspective discusses recent clinical and biomedical applications of Raman spectroscopy and technological advancements that provide valuable insights and encouragement for resolving some of the most challenging hurdles.

Keywords: Clinical translation; Point of care diagnosis; Raman spectroscopy; Surface-enhanced Raman spectroscopy.

Publication types

Review