It's lights out for presynaptic terminals

Xinyi Jenny He; Matthew R Banghart

doi:10.1016/j.neuron.2021.05.015

It's lights out for presynaptic terminals

Neuron. 2021 Jun 2;109(11):1755-1757. doi: 10.1016/j.neuron.2021.05.015.

Authors

Xinyi Jenny He¹, Matthew R Banghart²

Affiliations

¹ Division of Biological Sciences, Neurobiology Section, University of California San Diego, La Jolla, CA 92093, USA.
² Division of Biological Sciences, Neurobiology Section, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: mbanghart@ucsd.edu.

PMID: 34081915
DOI: 10.1016/j.neuron.2021.05.015

Abstract

Reliable optogenetic tools for sustained, projection-specific presynaptic silencing have been elusive. Recently in Neuron, Mahn et al. (2021) and Copits et al. (2021) describe how the light-activated inhibitory GPCRs eOPN3 and PPO can be used to reversibly suppress synaptic transmission in mice.

Keywords: GPCR; dopamine; optogenetics; presynaptic; rhodopsin; silencing; synaptic transmission.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Culicidae*
Mice
Neurotransmitter Agents
Optogenetics
Presynaptic Terminals*
Rhodopsin
Synaptic Transmission

Substances

Neurotransmitter Agents
Rhodopsin

Abstract

Publication types

MeSH terms

Substances

Grants and funding