TBK1 haploinsufficiency in ALS and FTD compromises membrane trafficking

Acta Neuropathol. 2021 Jul;142(1):217-221. doi: 10.1007/s00401-021-02331-1. Epub 2021 Jun 3.

Authors

Yubing Lu^{1

2}, Sandra Almeida³, Fen-Biao Gao⁴

Affiliations

¹ Department of Neurology, University of Massachusetts Medical School, Worcester, MA, 01605, USA. yxl2282@case.edu.
² Department of Pathology, Case Western Reserve University, Cleveland, OH, 44106, USA. yxl2282@case.edu.
³ Department of Neurology, University of Massachusetts Medical School, Worcester, MA, 01605, USA.
⁴ Department of Neurology, University of Massachusetts Medical School, Worcester, MA, 01605, USA. fen-biao.gao@umassmed.edu.

No abstract available

Keywords: ALS; FTD; Membrane trafficking; Neurons; TBK 1; iPSC.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Amyotrophic Lateral Sclerosis / genetics*
Cell Line, Tumor
Frontotemporal Dementia / genetics*
Green Fluorescent Proteins / genetics
HEK293 Cells
Haploinsufficiency / genetics*
Humans
Protein Serine-Threonine Kinases / genetics*
Qa-SNARE Proteins / genetics

Substances

Qa-SNARE Proteins
STX12 protein, human
enhanced green fluorescent protein
Green Fluorescent Proteins
Protein Serine-Threonine Kinases
TBK1 protein, human

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