Computer-assisted ultrasound assessment of plaque characteristics in radiation-induced and non-radiation-induced carotid atherosclerosis

Yuanxi Li; Dora Lai-Wan Kwong; Vincent Wing-Cheung Wu; Shea-Ping Yip; Helen Ka-Wai Law; Shara Wee-Yee Lee; Michael Tin-Cheung Ying

doi:10.21037/qims-20-1012

Computer-assisted ultrasound assessment of plaque characteristics in radiation-induced and non-radiation-induced carotid atherosclerosis

Quant Imaging Med Surg. 2021 Jun;11(6):2292-2306. doi: 10.21037/qims-20-1012.

Authors

Yuanxi Li¹, Dora Lai-Wan Kwong², Vincent Wing-Cheung Wu¹, Shea-Ping Yip¹, Helen Ka-Wai Law¹, Shara Wee-Yee Lee¹, Michael Tin-Cheung Ying¹

Affiliations

¹ Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China.
² Department of Clinical Oncology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.

Abstract

Background: This study investigated the feasibility of using a computer-assisted method to evaluate and differentiate the carotid plaque characteristics in radiation-induced and non-radiation-induced carotid atherosclerosis.

Methods: This study included 107 post-radiotherapy (post-RT) nasopharyngeal carcinoma (NPC) patients and 110 subjects with cardiovascular risk factors (CVRFs). Each participant had a carotid ultrasound examination, and carotid plaques and carotid intima-media thickness (CIMT) were evaluated with grey scale ultrasound. The carotid plaque characteristics were evaluated for grey-scale median (GSM) and detailed plaque texture analysis (DPTA) using specific computer software. In DPTA, five different intra-plaque components were colour-coded according to different grey scale ranges. A multivariate linear regression model was used to evaluate the correlation of risk factors and carotid plaque characteristics.

Results: Post-RT NPC patients have significantly higher CIMT (748±15.1 µm, P=0.001), more patients had a plaque formation (80.4%, P<0.001) and more plaque locations (2.3±0.2, P<0.001) than CVRF subjects (680.4±10.0 µm, 38.2% and 0.5±0.1 respectively). Among the five intra-plaque components, radiation-induced carotid plaques had significantly larger area of calcification (4.8%±7.7%, P=0.012), but lesser area of lipid (42.1%±16.9%, P=0.034) when compared to non-radiation-induced carotid plaques (3.0%±5.7% and 46.3%±17.9% respectively). Age, radiation and number of CVRF were significantly associated with the carotid atherosclerosis burden (P<0.001). Besides, age was significantly associated with the amount of lipid and calcification within carotid plaques (P<0.001).

Conclusions: Radiation caused more severe carotid artery disease than CVRF with larger CIMT and more prevalent of carotid plaque. Radiation-induced carotid plaques tended to have more intra-plaque calcifications, whereas non-radiation-induced carotid plaques had more lipids. Ultrasound aided by computer-assisted image analysis has potential for more accurate assessment of carotid atherosclerosis.

Keywords: Atherosclerotic plaque; carotid atherosclerosis; radiation effects; ultrasound.