Relationship Between Estradiol and Hemostasis Determined Through Thromboelastography Profile in Controlled Ovarian Stimulation Cycles

Wiryawan Permadi; Mulyanusa Amarullah Ritonga; Hartanto Bayuaji; Niswan Helja; Corina Delarosa Khoirunnisa; Tono Djuwantono

doi:10.2147/JBM.S293434

Relationship Between Estradiol and Hemostasis Determined Through Thromboelastography Profile in Controlled Ovarian Stimulation Cycles

J Blood Med. 2021 May 27:12:361-368. doi: 10.2147/JBM.S293434. eCollection 2021.

Authors

Wiryawan Permadi¹, Mulyanusa Amarullah Ritonga¹, Hartanto Bayuaji¹, Niswan Helja¹, Corina Delarosa Khoirunnisa¹, Tono Djuwantono¹

Affiliation

¹ Department of Obstetrics & Gynecology, Dr. Hasan Sadikin Hospital, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia.

Abstract

Purpose: We aimed to analyze the relationship between estradiol level and thromboelastography profile.

Patients and methods: This prospective study with comparative analysis was performed on nineteen samples undergoing an IVF procedure in two fertility clinics in Bandung city. Blood samples taken on the second and twelfth days of the IVF cycle.

Results: There were significant differences in the value of estradiol, fibrin formation time (α), and coagulation index (CI) (p<0.05). Correlation tests showed no relationship and no significant correlation between an increased level of estradiol and coagulation index (CI) (r _s=0.054; p=0.827) and between an increased level of estradiol and fibrinolysis time (LY30) (r _s=-0.151; p=0.536). A moderate significant relationship was observed between age and coagulation index (CI) (r _s=-0.430; p=0.033) and between age and maximum amplitude (MA) (r _s=-0.494; p=0.032).

Conclusion: Supraphysiological estradiol levels in controlled ovarian stimulation cycles affect the coagulation index and change mainly the fibrin formation time.

Keywords: controlled ovarian cycles; estradiol; hemostasis; thromboelastography.