Role of Pyroptosis in Diabetes and Its Therapeutic Implications

Abdullah Al Mamun; Yanqing Wu; Fatema Nasrin; Afroza Akter; Masuma Afrin Taniya; Fahad Munir; Chang Jia; Jian Xiao

doi:10.2147/JIR.S291453

Role of Pyroptosis in Diabetes and Its Therapeutic Implications

J Inflamm Res. 2021 May 24:14:2187-2206. doi: 10.2147/JIR.S291453. eCollection 2021.

Authors

Abdullah Al Mamun¹, Yanqing Wu², Fatema Nasrin^{3

4}, Afroza Akter⁵, Masuma Afrin Taniya⁶, Fahad Munir⁷, Chang Jia⁸, Jian Xiao¹

Affiliations

¹ Department of Hand Surgery and Peripheral Neurosurgery, The First Affiliated Hospital and School of Pharmaceutical Sciences, Wenzhou, Zhejiang Province, 325035, People's Republic of China.
² Institute of Life Sciences, Wenzhou University, Wenzhou, Zhejiang Province, 325035, People's Republic of China.
³ Institute of Health and Biomedical Innovation, Translational Research Institute, Brisbane, Australia.
⁴ School of Clinical Sciences, Queensland University of Technology, Brisbane, Australia.
⁵ Department of Microbiology, Noakhali Science and Technology University, Noakhali, Bangladesh.
⁶ Department of Life Sciences, School of Environment and Life Sciences, Independent University, Bangladesh, Dhaka, 1229, Bangladesh.
⁷ Department of Hepatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, People's Republic of China.
⁸ Pediatric Research Institute, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang Province, People's Republic of China.

Abstract

Pyroptosis is mainly considered as a new pro-inflammatory mediated-programmed cell death. In addition, pyroptosis is described by gasdermin-induced pore formation on the membrane, cell swelling and rapid lysis, and several pro-inflammatory mediators interleukin-1β (IL-1β) and interleukin-18 (IL-18) release. Extensive studies have shown that pyroptosis is commonly involved by activating the caspase-1-dependent canonical pathway and caspase-4/5/11-dependent non-canonical pathway. However, pyroptosis facilitates local inflammation and inflammatory responses. Current researches have reported that pyroptosis promotes the progression of several diabetic complications. Emerging studies have suggested that some potential molecules targeting the pyroptosis and inflammasome signaling pathways could be a novel therapeutic avenue for managing and treating diabetes and its complications in the near future. Our narrative review concisely describes the possible mechanism of pyroptosis and its progressive understanding of the development of diabetic complications.

Keywords: GSDMD; IL-18; IL-1β; NLRP3; caspase-1; diabetes; pyroptosis.

Publication types

Review

Grants and funding

This work was supported by the Natural Science Foundation of China (81972150, 81722028, 81801233); Natural Science Foundation of Zhejiang Province (LR18H50001), Research Unit of Research and Clinical Translation of Cell Growth Factors and Diseases of Chinese Academy of Medical Science (2019RU010).