Bisphenol S (BPS) is an organic chemical that has been used as a substitute for bisphenol A (BPA) in making polycarbonate plastics, epoxy resins, thermal receipt papers, and currency bills, as BPA has been reported to have dreadful effects on the living system. From this view point, the present study investigates whether BPS has the same or rather more toxic effects like BPA or not. Limited studies were carried out on the effect of BPS on fish. The hepatic antioxidant enzymes such as superoxide dismutase, catalase, glutathione S-transferase, glutathione reductase, and glutathione peroxidase (GPx), along with the nonenzymatic antioxidant, glutathione, in a freshwater fish, Labeo rohita, were selected as biomarkers. The results revealed that the sublethal exposure of BPS significantly influenced the activities of these biomarkers. Lipid peroxidation (LPO) products such as malondialdehyde and conjugate diene levels were also altered by the exposure. The alteration in the levels of antioxidants and LPO products after BPS exposure clearly showed that the fish experienced oxidative stress. Furthermore, the current study showed that BPS is a pollutant with oxidative potential by disrupting the antioxidant enzymes.
Keywords: antioxidants; biomarkers; bisphenol S; lipid peroxidation; oxidative stress.
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