Microstructured optical fibers sensor modified by deep eutectic solvent: Liquid-phase microextraction and detection in one analytical device

Pavel Pidenko; Christina Vakh; Andrey Shishov; Julia Skibina; Natalia Burmistrova; Andrey Bulatov

doi:10.1016/j.talanta.2021.122305

Microstructured optical fibers sensor modified by deep eutectic solvent: Liquid-phase microextraction and detection in one analytical device

Talanta. 2021 Sep 1:232:122305. doi: 10.1016/j.talanta.2021.122305. Epub 2021 Mar 27.

Authors

Pavel Pidenko¹, Christina Vakh², Andrey Shishov², Julia Skibina³, Natalia Burmistrova⁴, Andrey Bulatov²

Affiliations

¹ Institute of Chemistry, Saint Petersburg State University, RU-198504, Saint Petersburg, Russia; Institute of Chemistry, Saratov State University, RU-410012, Saratov, Russia. Electronic address: pidenkops@gmail.com.
² Institute of Chemistry, Saint Petersburg State University, RU-198504, Saint Petersburg, Russia.
³ SPE LLC Nanostructured Glass Technology, RU-410600, Saratov, Russia.
⁴ Institute of Chemistry, Saratov State University, RU-410012, Saratov, Russia.

PMID: 34074383
DOI: 10.1016/j.talanta.2021.122305

Abstract

A sensitive optical sensor based on hollow core microstructure optical fibers modified with deep eutectic solvent was produced for the first time. An easy procedure for the modification of hollow-core microstructure optical fibers with deep eutectic solvent was developed. Deep eutectic solvents based on natural monoterpenoids and fatty acids were investigated for glass surface modification. The sensor was used for the determination of non-steroidal anti-inflammatory drugs (mefenamic acid, diclofenac, flurbiprofen and ketoprofen) in human urine samples. The mechanism of the sensor response was investigated and discussed. Liquid-phase microextraction of non-steroidal anti-inflammatory drugs was implemented in deep eutectic solvent phase supported in the inner surface of hollow-core microstructure optical fibers followed by transmission spectra measurement in one analytical device. The preconcentration step performed directly in the analytical device allowed to obtain high sensitivity and selectivity. The limits of detection calculated from the calibration plots based on 3σ were 3 μg L^-1 for all target analytes.

Keywords: Deep eutectic solvents; Hollow-core microstructure optical fibers; Liquid-phase microextraction; Non-steroidal anti-inflammatory drugs; Optical fiber sensor; Urine.