Sulforaphane Impact on Reactive Oxygen Species (ROS) in Bladder Carcinoma

Int J Mol Sci. 2021 May 31;22(11):5938. doi: 10.3390/ijms22115938.

Abstract

Sulforaphane (SFN) is a natural glucosinolate found in cruciferous vegetables that acts as a chemopreventive agent, but its mechanism of action is not clear. Due to antioxidative mechanisms being thought central in preventing cancer progression, SFN could play a role in oxidative processes. Since redox imbalance with increased levels of reactive oxygen species (ROS) is involved in the initiation and progression of bladder cancer, this mechanism might be involved when chemoresistance occurs. This review summarizes current understanding regarding the influence of SFN on ROS and ROS-related pathways and appraises a possible role of SFN in bladder cancer treatment.

Keywords: Keap1-Nrf2; ROS; bladder cancer; oxidative stress; sulforaphane.

Publication types

  • Review

MeSH terms

  • Animals
  • Anticarcinogenic Agents* / pharmacology
  • Anticarcinogenic Agents* / therapeutic use
  • Antioxidants* / pharmacology
  • Antioxidants* / therapeutic use
  • Carcinoma / drug therapy*
  • Cell Line, Tumor
  • Humans
  • Isothiocyanates* / pharmacology
  • Isothiocyanates* / therapeutic use
  • Kelch-Like ECH-Associated Protein 1 / metabolism
  • NF-E2-Related Factor 2 / metabolism
  • Reactive Oxygen Species / metabolism
  • Sulfoxides* / pharmacology
  • Sulfoxides* / therapeutic use
  • Urinary Bladder Neoplasms / drug therapy*

Substances

  • Anticarcinogenic Agents
  • Antioxidants
  • Isothiocyanates
  • KEAP1 protein, human
  • Kelch-Like ECH-Associated Protein 1
  • NF-E2-Related Factor 2
  • NFE2L2 protein, human
  • Reactive Oxygen Species
  • Sulfoxides
  • sulforaphane