Stemodane Diterpenes and Diterpenoids: Isolation, Structure Elucidation, Biogenesis, Biosynthesis, Biological Activity, Biotransformations, Metabolites and Derivatives Biological Activity, Rearrangements

Francesca Leonelli; Luisa Maria Migneco; Alessio Valletta; Rinaldo Marini Bettolo

doi:10.3390/molecules26092761

Stemodane Diterpenes and Diterpenoids: Isolation, Structure Elucidation, Biogenesis, Biosynthesis, Biological Activity, Biotransformations, Metabolites and Derivatives Biological Activity, Rearrangements

Molecules. 2021 May 7;26(9):2761. doi: 10.3390/molecules26092761.

Authors

Francesca Leonelli¹, Luisa Maria Migneco¹, Alessio Valletta², Rinaldo Marini Bettolo¹

Affiliations

¹ Dipartimento di Chimica, Università degli Studi La Sapienza, Piazzale Aldo Moro 5, I-00185 Roma, Italy.
² Dipartimento di Biologia Ambientale, Università degli Studi La Sapienza, Piazzale Aldo Moro 5, I-00185 Roma, Italy.

Abstract

The scientific activity carried out over forty-five years on stemodane diterpenes and diterpenoids structure elucidation, biogenesis, biosynthesis, biological activity and biotransformations was reviewed.

Keywords: bioactivity; biogenesis; biosynthesis; biotransformations; diterpenes; diterpenoids; isolation; stemodane; structure.

Publication types

Review

MeSH terms

Biosynthetic Pathways
Biotransformation / drug effects
Diterpenes / chemistry*
Diterpenes / isolation & purification*
Diterpenes / metabolism
Diterpenes / pharmacology
Lipid Peroxidation / drug effects
Metabolome* / drug effects

Substances

Diterpenes