Ultrasonic Synthesis and Biomedical Application of Mn0.5Zn0.5ErxYxFe2-2xO4 Nanoparticles

Suriya Rehman; Munirah A Almessiere; Ebtesam A Al-Suhaimi; Mehwish Hussain; Maha Yousuf Bari; Syed Mehmood Ali; Suhailah S Al-Jameel; Yassine Slimani; Firdos Alam Khan; Abdulhadi Baykal

doi:10.3390/biom11050703

Ultrasonic Synthesis and Biomedical Application of Mn_0.5Zn_0.5Er_xY_xFe_2-2xO₄ Nanoparticles

Biomolecules. 2021 May 8;11(5):703. doi: 10.3390/biom11050703.

Affiliations

¹ Department of Epidemic Diseases Research, Institute for Research & Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, 31441 Dammam, Saudi Arabia.
² Department of Biophysics, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441 Dammam, Saudi Arabia.
³ Biology Department, College of Science, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441 Dammam, Saudi Arabia.
⁴ Department of Public Health, College of Public Health, Imam Abdulrahman Bin Faisal University, 31441 Dammam, Saudi Arabia.
⁵ Department of English, Deanship of Preparatory Year, Imam Abdulrahman Bin Faisal University, 31441 Dammam, Saudi Arabia.
⁶ Department of Biomedical Engineering, College of Engineering, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441 Dammam, Saudi Arabia.
⁷ Department of Chemistry, College of Science, Imam Abdulrahman Bin Faisal University, 31441 Dammam, Saudi Arabia.
⁸ Department of Stem Cell Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441 Dammam, Saudi Arabia.
⁹ Department of Nano-Medicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441 Dammam, Saudi Arabia.

Abstract

In the present study, biocompatible manganese nanoparticles have been linked with zinc and iron molecules to prepare different derivatives of Mn_0.5Zn_0.5Er_xY_xFe_2-2xO₄ NPs (x = 0.02, 0.04, 0.06, 0.08, 0.10), using an ultrasonication approach. The structure, surface morphology, and chemical compositions of Mn_0.5Zn_0.5Er_xY_xFe_2-2xO₄ NPs were elucidated by X-ray diffractometer (XRD), High-resolution transmission electron microscopy (HR-TEM), scanning electron microscope (SEM), and Energy Dispersive X-Ray Analysis (EDX) techniques. The bioactivity of Mn_0.5Zn_0.5Er_xY_xFe_2-2xO₄ NPs on normal (HEK-293) and (HCT-116) colon cancer cell line was evaluated. The Mn_0.5Zn_0.5Er_xY_xFe_2-2xO₄ NPs treatment post 48 h resulted in a significant reduction in cells (via MTT assay, having an IC₅₀ value between 0.88 µg/mL and 2.40 µg/mL). The specificity of Mn_0.5Zn_0.5Er_xY_xFe_2-2xO₄ NPs were studied by treating them on normal cells line (HEK-293). The results showed that Mn_0.5Zn_0.5Er_xY_xFe_2-2xO₄ NPs did not incur any effect on HEK-293, which suggests that Mn_0.5Zn_0.5Er_xY_xFe_2-2xO₄ NPs selectively targeted the colon cancerous cells. Using Candida albicans, antifungal activity was also studied by evaluating minimum inhibitory/fungicidal concentration (MIC/MFC) and the effect of nanomaterial on the germ tube formation, which exhibited that NPs significantly inhibited the growth and germ tube formation. The obtained results hold the potential to design nanoparticles that lead to efficient bioactivity.

Keywords: anti colon cancer activity; antifungal activity; biomedical; magnetic nanoparticles; ultrasonication.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / pharmacology*
Antineoplastic Agents / pharmacology*
Candida albicans / drug effects
Cell Line, Tumor
Erbium / chemistry
Humans
Manganese / chemistry
Metal Nanoparticles / administration & dosage*
Metal Nanoparticles / chemistry
Neoplasms / drug therapy*
Neoplasms / metabolism
Neoplasms / pathology
Oxides / chemistry*
Ultrasonic Waves
Yttrium / chemistry
Zinc / chemistry

Substances

Antifungal Agents
Antineoplastic Agents
Oxides
Manganese
Yttrium
Erbium
Zinc