Voltammetric determination of norepinephrine in the presence of acetaminophen using a novel ionic liquid/multiwall carbon nanotubes paste electrode

Sadegh Salmanpour; Toktam Tavana; Ali Pahlavan; Mohammad A Khalilzadeh; Ali A Ensafi; Hassan Karimi-Maleh; Hadi Beitollahi; Elaheh Kowsari; Daryoush Zareyee

doi:10.1016/j.msec.2012.05.038

Voltammetric determination of norepinephrine in the presence of acetaminophen using a novel ionic liquid/multiwall carbon nanotubes paste electrode

Mater Sci Eng C Mater Biol Appl. 2012 Oct 1;32(7):1912-1918. doi: 10.1016/j.msec.2012.05.038. Epub 2012 May 28.

Authors

Sadegh Salmanpour¹, Toktam Tavana², Ali Pahlavan³, Mohammad A Khalilzadeh⁴, Ali A Ensafi⁵, Hassan Karimi-Maleh⁶, Hadi Beitollahi⁷, Elaheh Kowsari⁸, Daryoush Zareyee²

Affiliations

¹ Department of Chemistry, Sari Branch, Islamic Azad University, Sari, Iran.
² Department of Chemistry, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran.
³ Department of Physics, Science and Research Branch, Islamic Azad University, Mazandaran, Iran.
⁴ Department of Chemistry, Science and Research Branch, Islamic Azad University, Mazandaran, Iran. Electronic address: khalilzadeh73@yahoo.com.
⁵ Department of Chemistry, Isfahan University of Technology, Isfahan, Iran.
⁶ Department of Chemistry, Science and Research Branch, Islamic Azad University, Mazandaran, Iran. Electronic address: h.karimi.maleh@gmail.com.
⁷ Environment Department, Research Institute of Environmental Sciences, International Center for Science, High Technology & Environmental Sciences, Kerman, Iran.
⁸ Department of Chemistry, Amirkabir University of Technology, No. 424, Hafez Avenue, Tehran, Iran.

PMID: 34062675
DOI: 10.1016/j.msec.2012.05.038

Abstract

A novel multiwall carbon nanotubes (MWCNTs) modified carbon ionic liquid electrode (CILE) was fabricated and used to investigate the electrochemical behavior of norepinephrine (NP). MWCNTs/CILE was prepared by mixing hydrophilic ionic liquid, 1-methyl-3-butylimidazolium bromide (MBIDZBr), with graphite powder, MWCNTs, and liquid paraffin. The fabricated MWCNTs/CILE showed great electrocatalytic ability to the oxidation of NE. The electron transfer coefficient, diffusion coefficient, and charge transfer resistant (R_ct) of NE at the modified electrode were calculated. Differential pulse voltammetry of NE at the modified electrode exhibited two linear dynamic ranges with slopes of 0.0841 and 0.0231μA/μM in the concentration ranges of 0.3 to 30.0μM and 30.0 to 450.0μM, respectively. The detection limit (3σ) of 0.09μM NP was achieved. This modified electrode exhibited a good ability for well separated oxidation peaks of NE and acetaminophen (AC) in a buffer solution, pH 7.0. The proposed sensor was successfully applied for the determination of NE in human urine, pharmaceutical, and serum samples.

Keywords: Acetaminophen; Ionic liquid; Multiwall carbon nanotubes; Norepinephrine; Voltammetry.