Activation of Rac1-Mineralocorticoid Receptor Pathway Contributes to Renal Injury in Salt-Loaded db/db Mice

Hypertension. 2021 Jul;78(1):82-93. doi: 10.1161/HYPERTENSIONAHA.121.17263. Epub 2021 Jun 1.

Authors

Daigoro Hirohama^{1

2}, Mitsuhiro Nishimoto^{1

3}, Nobuhiro Ayuzawa¹, Wakako Kawarazaki¹, Wataru Fujii², Shigeyoshi Oba¹, Shigeru Shibata^{1

2}, Takeshi Marumo^{1

4}, Toshiro Fujita^{1

5

6}

Affiliations

¹ Division of Clinical Epigenetics, Research Center for Advanced Science and Technology, The University of Tokyo, Japan (D.H., M.N., N.A., W.K., S.O., S.S., T.M., T.F.).
² Division of Nephrology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan (D.H., W.F., S.S.).
³ Department of Internal Medicine, International University of Health and Welfare Mita Hospital, Tokyo, Japan (M.N.).
⁴ Department of Pharmacology, School of Medicine, International University of Health and Welfare, Chiba, Japan (T.M.).
⁵ Shinshu University School of Medicine (T.F.), Shinshu University, Nagano, Japan.
⁶ Research Center for Social Systems (T.F.), Shinshu University, Nagano, Japan.

PMID: 34058848
DOI: 10.1161/HYPERTENSIONAHA.121.17263

Abstract

[Figure: see text].

Keywords: aldosterone; diabetic kidney disease; hypertension; mineralocorticoid receptor; sodium.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aminoquinolines / pharmacology
Animals
Blood Pressure / drug effects
Blood Pressure / physiology
Diabetes Mellitus, Type 2 / etiology
Diabetes Mellitus, Type 2 / metabolism*
Diabetes Mellitus, Type 2 / physiopathology
Epithelial Sodium Channels / genetics
Epithelial Sodium Channels / metabolism
Gene Expression / drug effects
Immediate-Early Proteins / genetics
Immediate-Early Proteins / metabolism
Kidney / metabolism*
Kidney / pathology
Male
Mice
Naphthyridines / pharmacology
Obesity / etiology
Obesity / metabolism*
Obesity / physiopathology
Protein Serine-Threonine Kinases / genetics
Protein Serine-Threonine Kinases / metabolism
Pyrimidines / pharmacology
Receptors, Mineralocorticoid / metabolism*
Signal Transduction / drug effects
Signal Transduction / physiology*
Sodium Chloride, Dietary / administration & dosage
Sodium Chloride, Dietary / adverse effects
rac1 GTP-Binding Protein / antagonists & inhibitors
rac1 GTP-Binding Protein / metabolism*

Substances

Aminoquinolines
Epithelial Sodium Channels
Immediate-Early Proteins
NSC 23766
Naphthyridines
Pyrimidines
Receptors, Mineralocorticoid
Sodium Chloride, Dietary
finerenone
Protein Serine-Threonine Kinases
serum-glucocorticoid regulated kinase
rac1 GTP-Binding Protein