The Potential Application of Magnetic Nanoparticles for Liver Fibrosis Theranostics

Aziz Eftekhari; Allahveirdy Arjmand; Ayyub Asheghvatan; Helena Švajdlenková; Ondrej Šauša; Huseyn Abiyev; Elham Ahmadian; Oleh Smutok; Rovshan Khalilov; Taras Kavetskyy; Magali Cucchiarini

doi:10.3389/fchem.2021.674786

The Potential Application of Magnetic Nanoparticles for Liver Fibrosis Theranostics

Front Chem. 2021 May 14:9:674786. doi: 10.3389/fchem.2021.674786. eCollection 2021.

Authors

Aziz Eftekhari^{1

2

3

4}, Allahveirdy Arjmand¹, Ayyub Asheghvatan¹, Helena Švajdlenková², Ondrej Šauša^{5

6}, Huseyn Abiyev⁷, Elham Ahmadian⁸, Oleh Smutok^{9

10}, Rovshan Khalilov^{3

11

12}, Taras Kavetskyy^{4

5

13}, Magali Cucchiarini¹⁴

Affiliations

¹ Maragheh University of Medical Sciences, Maragheh, Iran.
² Polymer Institute, Slovak Academy of Sciences, Bratislava, Slovakia.
³ Russian Institute for Advanced Study, Moscow State Pedagogical University, Moscow, Russian Federation.
⁴ Department of Surface Engineering, The John Paul II Catholic University of Lublin, Lublin, Poland.
⁵ Institute of Physics, Slovak Academy of Sciences, Bratislava, Slovakia.
⁶ Department of Nuclear Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia.
⁷ Department of Biochemistry, Azerbaijan Medical University, Baku, Azerbaijan.
⁸ Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
⁹ Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY, United States.
¹⁰ Institute of Cell Biology, National Academy of Sciences of Ukraine, Lviv, Ukraine.
¹¹ Department of Biophysics and Biochemistry, Baku State University, Baku, Azerbaijan.
¹² Institute of Radiation Problems, National Academy of Sciences of Azerbaijan, Baku, Azerbaijan.
¹³ Department of Biology and Chemistry, Drohobych Ivan Franko State Pedagogical University, Drohobych, Ukraine.
¹⁴ Center of Experimental Orthopaedics, Saarland University Medical Center, Homburg, Germany.

Abstract

Liver fibrosis is a major cause of morbidity and mortality worldwide due to chronic liver damage and leading to cirrhosis, liver cancer, and liver failure. To date, there is no effective and specific therapy for patients with hepatic fibrosis. As a result of their various advantages such as biocompatibility, imaging contrast ability, improved tissue penetration, and superparamagnetic properties, magnetic nanoparticles have a great potential for diagnosis and therapy in various liver diseases including fibrosis. In this review, we focus on the molecular mechanisms and important factors for hepatic fibrosis and on potential magnetic nanoparticles-based therapeutics. New strategies for the diagnosis of liver fibrosis are also discussed, with a summary of the challenges and perspectives in the translational application of magnetic nanoparticles from bench to bedside.

Keywords: drug delivery; liver fibrosis; magnetic nanoparticles; nanomedicine; theranostics.

Publication types

Review