Altered Neurovascular Coupling in Subcortical Ischemic Vascular Disease

Xiaoshuang Liu; Runtian Cheng; Li Chen; Junwei Gong; Tianyou Luo; Fajin Lv

doi:10.3389/fnagi.2021.598365

Altered Neurovascular Coupling in Subcortical Ischemic Vascular Disease

Front Aging Neurosci. 2021 May 12:13:598365. doi: 10.3389/fnagi.2021.598365. eCollection 2021.

Authors

Xiaoshuang Liu¹, Runtian Cheng¹, Li Chen², Junwei Gong¹, Tianyou Luo¹, Fajin Lv¹

Affiliations

¹ Department of Radiology, First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
² Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Sichuan, China.

Abstract

Patients with subcortical ischemic vascular disease (SIVD) exhibit a high risk of cognitive impairment that might be caused by neurologic deficits and vascular injuries. However, the mechanism remains unknown. In current study, 24 normal controls (NC) and 54 SIVD patients, including 26 SIVD patients with no cognitive impairment (SIVD-NCI) and 28 SIVD patients with mild cognitive impairment (SIVD-MCI) underwent the resting-state functional MRI (rs-fMRI) and neuropsychological assessments. We combined regional homogeneity (ReHo) and cerebral blood flow (CBF) by using the global ReHo-CBF correlations coefficient and the ReHo/CBF ratio to detect the inner link between neuronal activity and vascular responses. Correlations between the ReHo/CBF ratio and neuropsychological assessments were explored in patients with SIVD. As a result, we identified significantly decreased global ReHo-CBF coupling in the SIVD-NCI group and SIVD- MCI group with respect to the NC. The SIVD-MCI group showed more serious decoupling of the global ReHo-CBF correlation. We also found a significantly abnormal ReHo/CBF ratio predominantly located in cognitive-related brain regions, including the left insula, right middle temporal gyrus, right precuneus, left precentral gyrus, and left inferior parietal lobule but not the supramarginal and angular gyri. The SIVD-MCI group showed more severe disorders of neurovascular coupling than the other two groups. Moreover, the ReHo/CBF ratio in the left precentral gyrus of the SIVD-NCI group exhibited a positive correlation with the MMSE scores. These findings suggested that patients with SIVD show abnormal neurovascular coupling at the early stage of the disease and during disease development. It might be associated with disease severity and cognitive impairment. Neurovascular decoupling in brain may be a possible neuropathological mechanism of SIVD.

Keywords: arterial spin labeling; cerebral blood flow; cognitive deficit; functional magnetic resonance imaging; neurovascular coupling; subcortical ischemic vascular disease.