Oxidative phosphorylation system and cell culture media

Trends Cell Biol. 2021 Aug;31(8):618-620. doi: 10.1016/j.tcb.2021.05.003. Epub 2021 May 26.

Abstract

Traditional culture media do not resemble the metabolic composition of human blood. The concentration of different metabolites in these media influences mitochondrial biogenesis and oxidative phosphorylation (OXPHOS) function. This knowledge is essential for the interpretation of results obtained from cellular models used for the study of OXPHOS function.

Keywords: cell culture media; cell model; mitochondrial biogenesis; oxidative phosphorylation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Culture Techniques
  • Humans
  • Organelle Biogenesis*
  • Oxidative Phosphorylation*